PUBLICATIONS
• Shengyu Li#, Pengzhi Zhang#, Weiqing Chen , Lingqun Ye, Kristopher W. Brannan, Nhat-Tu Le, Jun-ichi Abe, John P. Cooke, Guangyu Wang. A relay velocity model infers cell-dependent RNA velocity. Nature Biotechnology (2023): https://www.nature.com/articles/s41587-023-01728-5
• Zhou P, VanDusen NJ, Zhang Y, Cao Y, Sethi I, Hu R, Zhang S, Wang G, Ye L, Mazumdar N, Chen J, Zhang X, Guo Y, Li B, Ma Q, Lee JY, Gu W, Yuan GC, Ren B, Chen K, Pu WT. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev Cell. 2023 doi: 10.1016/j.devcel.2023.03.020. Epub ahead of print. PMID: 37071996.
• Jie Lv, Shu Meng, Qilin Gu, Rongbin Zheng, Xinlei Gao, Jun-dae Kim, Min Chen, Bo Xia, Yihan Zuo, Sen Zhu, Dongyu Zhao, Yanqiang Li, Guangyu Wang, Xin Wang, Qingshu Meng, Qi Cao, John P Cooke, Longhou Fang, Kaifu Chen, Lili Zhang. Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nat Commun 14, 2390 (2023). https://doi.org/10.1038/s41467-023-38002-w
• Krishan Gupta#,Guangyu Wang#, Shuo Zhang#, Xinlei Gao, Rongbin Zheng, Yanchun Zhang, Qingshu Meng, Lili Zhang, Qi Cao, Kaifu Chen. StripeDiff: Model-based Algorithm for Differential Analysis of Chromatin Stripe. Science Advances. (2022)
• Anahita Mojiri, Brandon K Walther, Chongming Jiang, Gianfranco Matrone, Rhonda Holgate, Qiu Xu, Elisa Morales, Guangyu Wang , Jianhua Gu, Rongfu Wang, John P Cooke. Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice. European Heart Journal. (2021)
• Guangyu Wang#, Bo Xia#, Joe Lv, Dongyu Zhao, Yanqiang Li, Yiwen Bu, Xin Wang, John P. Cooke, Qi Cao, Min Gyu Lee, Lili Zhang, Kaifu Chen. MACMIC reveals dual role of CTCF in epigenetic regulation of cell identity genes. Genomics, Proteomics, and Bioinformatics. (2021)
• Guangyu Wang, Qingshu Meng, Bo Xia, Shuo Zhang, Jie Lv, Dongyu Zhao, Yanqiang Li, Xin Wang, Lili Zhang, John P. Cooke, Qi Cao, Kaifu Chen. TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription. Genome Biology. (2020)
• Bo Xia#, Dongyu Zhao#, Guangyu Wang#, Min Zhang, Jie Lv, Alin S. Tomoiaga, Yanqiang Li, Xin Wang, Shu Meng, John P. Cooke, Qi Cao, Lili Zhang, Kaifu Chen. Machine Learning uncovers cell identity regulator by histone code. Nature Communication. (2020)
• Dongyu Zhao#, Lili Zhang#, Min Zhang, Bo Xia, Jie Lv, Guangyu Wang, Qingshu Meng, Yang Yi, Sen Zhu, Alin S. Tomoiaga, Min Gyu Lee, John P. Cooke, Qi Cao, Kaifu Chen. Widespread H3K27me3 Signifies Super Repression Domains for Enhanced Silencing of Oncogenes. Nature Communication. (2020)
• Guangyu Wang, Ana Sofia Cruz, Keith Youker, Hernan G Marcos-Abdala, Rajarajan A Thandavarayan, John P Cooke, Guillermo Torre-Amione, Kaifu Chen, Arvind Bhimaraj, Role of Endothelial and Mesenchymal cell transitions in heart failure and recovery thereafter. Frontiers in Genetics. (2020)
• Lin Liu#,Guangyu Wang#, Liguo Wang, Chunlei Yu, Mengwei Li, Shuhui Song, Lili Hao, Lina Ma, Zhang Zhang. Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling. Biology direct. (2020)
• Qiaqia Li#, Kilia Y. Liu#, Qipeng Liu#, Guangyu Wang#, Weihua Jiang, Qingshu Meng, Yang Yi, Yongyong Yang, Rui Wang, Sen Zhu, Chao Li, Lin Yan, Lili Zhang, Jung-Sun Kim, Xiongbing Zu, Jenny Chang, Anthony Kozielski, Wei Qian, Kaifu Chen, Qi Cao. Antihistamine Drug Ebastine inhibits cancer growth by targeting Polycomb Group Protein EZH2. Molecular Cancer Therapeutics. (2020)
• Guangyu Wang, Hongyan Yin, Boyang Li, Chunlei Yu, Fan Wang, Xingjian Xu, Jiabao Cao, Yiming Bao, Liguo Wang, Amir A Abbasi, Vladimir B Bajic, Lina Ma, Zhang Zhang. Characterization and identification of long noncoding RNAs based on feature relationship. Bioinformatics. (2019)
• Qipeng Liu#, Guangyu Wang#, Qiaqia Li#, Weihua Jiang, Jung-sun Kim, Rui Wang, Sen Zhu, Xiaoju Wang, Lin Yan, Yang Yi, Lili Zhang, Qingshu Meng, Chao Li, Yuanyuan Qiao, Yong Li, Demirkan B. Gursel, Arul M. Chinnaiyan, Kaifu Chen, Qi Cao. Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer. International Journal of Cancer. (2019)
• Long Zhi, Yinan Li, Gan Yu, Zhao Dongyu, Guangyu Wang, Xie Ning, Lovnicki Jessica M, Fali Ladan, Cao Qi, Chen Kaifu, Dong Xuesen. Roles of the HOXA10 Gene during Castrate Resistant Prostate Cancer Progression. Endocrine-Related Cancer. (2019)
• Sen Zhu, Dongyu Zhao, Chao Li, Qiaqia Li, Weihua Jiang, Qipeng Liu, Rui Wang, Ladan Fazli, Yinan Li, Lili Zhang, Yang Yi, Qingshu Meng, Wanyi Wang, Guangyu Wang, Min Zhang, Xiongbing Zu, Wei Zhao, Tuo Deng, Jindan Yu, Xuesen Dong, Kaifu Chen, Qi Cao. BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer. Oncogene (2019)
• Yang Yu#, Nhung Pham#, Bo Xia#, Alma Papusha, Guangyu Wang, Zhenxin Yan, Guang Peng, Kaifu Chen, Grzegorz Ira. Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks. Nature. (2018)
• Guangyu Wang# listed in BIG Data Center Members (2017) Database resources of the BIG Data Center in 2018. Nucleic Acids Res. (2018)
• Guangyu Wang# listed in BIG Data Center Members (2017) The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res. (2017)
• Hongyan Yin#, Guangyu Wang#, Lina Ma, Soojin V. Yi, Zhang Zhang. What Signatures Dominantly Associate with Gene Age? Genome biology and evolution. (2016)
• Hongyan Yin, Lina Ma, Guangyu Wang#, Mengwei Li, Zhang Zhang. Old genes experience stronger translational selection than young genes. Gene. (2016)
• Guangyu Wang, Shixiang Sun, Zhang Zhang. Randomness in Sequence Evolution Increases over Time. PLoS One. (2016)
• Cheng Xu#, Hongzhu Qu#, Guangyu Wang#, Bingbing Xie, Yi Shi, et al. A novel strategy for forensic age prediction by DNA methylation and support vector regression model. Scientific reports. (2015)